It is known that cardiovascular diseases (with myocardial infarction in the center) are the most deadly diseases in the West .
Epidemiological studies have for a long time shown a great heterogeneity of these diseases according to the countries of the globe.
Since the 1950s, we have been interested in this subject and it is Ancel KEYS who led at length and patiently what was then called “the study of the seven countries”.
These were the United States, Finland, Greece, Holland, Italy, Japan and Yugoslavia.
This study highlighted acoronary mortality (ie infarction) two to three times lower in southern Europe than in northern Europe and the USA.
Many other studies followed one another and opened up great prospects of prevention, at the food, behavioral and environmental levels, as well as the role of micronutrients.
Simple Pathophysiology and Cofactors
Atherosclerosis is the fundamental mechanism and is a multifactorial condition:
oxidative stress (tobacco – hypertension, etc.) with the proliferation of free radicals not compensated by the presence of antioxidants (vitamins, polyphenols, trace elements etc …
genetics related to polymorphism,
Feeding through several main mechanisms:
- excessive dietary intake of saturated and trans fats
- the imbalance of the metabolism of polyunsaturated fatty acids (imbalance between omega 6 and omega 3)
- the poverty of its density nutritional micronutrients.
Thus the genesis of the arteriosclerotic plaque is the consequence of a chronic inflammatory focus associated with a “disease” of the vessel wall (proliferation of smooth muscle cells, etc.), in particular linked to a cascade of reactions related to the LDL oxidation demonstrated by ox LDL levels.
Platelet aggregation will complete the thrombotic mechanism.
the essential roles of stress, sedentary lifestyle and pollution will be kept in mind.
Atherosclerosis is therefore an inflammatory disease in relation to oxidative stress .
This simplified reminder makes it possible to better develop a corrective strategy through,
Preventive, holistic and integrative care
Firstly the diet :
The diet will be, as in any process of oxidative stress, rich in plants, colored, often raw for the protection of polyphenols, non-industrial, as natural as possible and low glycemic load.
Two specificities are to be considered:
-The sufficient presence of omega 3 anti-inflammatory ; we will favor vegetable sources, rapeseed, first cold pressed and camel or flaxseed supplementation, but also marine intake in EPA / DHA.
The respect of food intolerances as proposed immunonutrition, to define a food anti -inflammatory specific to each case.
This diet is known in several versions very close, Mediterranean diet, Cretan diet, Diet DASH (Dietary Approach to Stop Hypertension), etc.
The fight against a sedentary lifestyle with a regular physical exercise, moderate, adapted to each one and the management of the stress by the approaches of “letting go” will complete the preventive strategy.
Micronutritional correction through certain phytonutrients represents a fundamental time.
1. First prevention of atherosclerosis and atherosclerotic plaque :
– For the correction of dyslipidemia: the Staticoncept 3
This original preparation combines the synergy of two active ingredients, the aged black garlic and hydroxytyrosol-oleuropein of olive oil.The effect of aged garlic extract(Its aging allowing the conversion of allicin from fresh garlic to S-allyl-cysteine, a more stable sulfur derivative) has been the subject of several studies in the journal Journal Nutritional in 2018: on the one hand, California and Dutch researchers have observed significantly fewer high-risk coronary plaques, garlic extract thus inhibiting the development of unstable lesions with necrotic center; On the other hand, Canadian researchers have found a significant cardiovascular effect, including blood pressure, cholesterolemia, CRP and coronary arterial calcification.
The hydroxytyrosol-oleuropein, the main phenolic compounds of olive oil, has great antioxidant properties, especially protective of blood lipids (including LDL cholesterol) against oxidative stress. All this has been officially recognized by the European Food Safety Authority (EFSA).
This complex is considered at the dosage of 2 capsules / day in the long term, to be adapted according to the case of each one.
– For a specific antioxidant: The Coenzyme Q10 Fort
CoQ10 is an essential antioxidant in the manufacture of energy by the mitochondria. It is synthesized by the liver especially and its synthesis decreases with aging. Its action is essential in cardiovascular diseases by its powerful antioxidant action, especially on lipids. In the proposed preparation, CoQ10 is obtained by fermentation, which gives it a good bioavailability and the presence of selenium contributes to an antioxidant synergy.
The effective dosage is 100 mg / day on average, 2 capsules / day to be taken rather with meals.
Too little known, the homocysteine rate, a marker of cardiovascular risk, is correlated with the risk of thickening of the vessel wall, but also is recognized in hypertension, oxidation of LDL and thrombosis.
– This rate depends on the body’s ability to “recycle” homocysteine to methionine and cysteine. This mechanism, known as the folate cycle, depends on genetic factors (MTHFR gene and its mutation), B vitamins and especially methyl (CH 3 ) radicals .
The MéthylSam’Active * (SAMe / S-adenosyl-L-methionine) is a methyl group universal donor: interest is therefore crucial in the recycle homocysteine.
Its dosage is 2 capsules at three meals, the time needed to correct the homocysteine level.
2. Then we will take care of low grade inflammation
– Omega 3
They are essential as modulators of chronic inflammation.
In particular those of marine origin such as EPA have a very important anti-inflammatory activity, more specifically on low grade inflammation. They reduce inflammation through the modulation of prostaglandin metabolism: decrease of pro-inflammatory PEG2, in favor of the increase of anti-inflammatory PEG3.
We will preferentially use the complex Omega 3 Fort (EPA / DHA combination) at the average dosage of 4 capsules / day, during mealsbut dosages should be adjusted upward as needed.
– Turmeric: the Curcuma
Curcuma after the Ayurvedic tradition, is the most powerful anti-inflammatory plant at our disposal. The publications are numerous and its anti-inflammatory action is the consequence of its action on the cellular metabolism of NFkB, much studied on the scientific level. The presence of Piperine greatly increases its bioavailability and makes this product a must.
Its dosage is 2 to 3 capsules / day, before breakfast and dinner.
3. And finally, we will correct the associated factors if present
Stress is recognized as a major risk factor in vascular diseases.
Saffron, rich in safranal, in crocin, has modulating effects on the levels of serotonin but also of dopamine. It reduces states of stress, nervousness and tension.
Dosage of 1 capsule 2 to 3 times / day , depending on the state of stress.
Keep in mind the role of Mg in stress and more generally in the stability of vasomotricity; the Magnesium Marino , thanks to its good bioavailability, at a dose of 2 / day , will be welcome.
Glucose balance: Gluciconcept
The metabolism of sugars is a very important factor in dyslipidemia, so the regulation of blood glucose is an essential time of correction.
The preparation Gluciconcept combines several active ingredients that act in this direction. Two hold our attention: on the one hand chromium, essential trace element, improves glucose tolerance. It acts in the body as a cofactor of insulin, it facilitates the uptake of glucose by the cells.
Thus participates in the normalization and the stabilization of blood glucose; on the other hand, gymnemic acid, extracted from the gymnema, has a hypoglycemic effect, insofar as it reduces the intestinal absorption of glucose and stimulates the production of insulin.
The dosage is 2 capsules at three meals on the necessary time, suitable for everyone.
advice Dietary advice is fundamental with the management of atherosclerosis with Staticoncept 3 , Coenzyme Q10 Fort , MethylSam’Active low-grade inflammation with Omega 3 Fort , Turmeric and finally cofactors (stress, etc.) with Safrazen , Magnesium-Marin and finally Gluciconcept .
Everything will be considered at the same time and will be adapted to each case and the long course.
The prevention of cardiovascular risks is an emergency in medicine, because it is a factor of morbidity and mortality very important in our Western societies: by putting in place a global strategy, in particular thanks to phytonutrients, one can legitimately hope to reduce the impact of these diseases.